Nolasco is 3-0 with a 0.76 ERA in three lifetime starts at AT&T Park, and his numbers against the Giants overall are just as eye-popping: 4-2 with a 1.61 ERA in six starts.
Nolasco, who remains two wins away from tying Dontrelle Willis' club record of 68, gets the start Tuesday in the opener of a three-game set between the Marlins and Giants. Righty Matt Cain goes for San Francisco in the fourth game of a nine-game homestand that just saw the Padres leave town, and the Brewers slated to come in next.
The Giants were off Monday, while the Marlins lost to the D-backs, 9-5, in the finale of a four-game series across the country in Florida. Tuesday is the start of a nine-game road trip for Miami.
Despite losses in eight of their last nine, Marlins manager Ozzie Guillen senses improvement.
"The last couple of days, our approach has been better," Guillen said this weekend. "We don't put a big inning together. When you don't put big innings together, it's going to be hard to score runs."
The Giants have won three of four, including the final two games against the Padres. Cain's previous outing -- 6 1/3 innings of three-run ball in a 9-2 loss to Cincinnati on Wednesday -- wasn't as good as the previous two, but that's not a fair comparison. Cain allowed a combined three hits in his previous two outings, both of them encompassing nine scoreless innings, with 15 strikeouts and just one walk.
"He's one of the best in the league," Cincinnati manager Dusty Baker said. "If you don't get to him early, you saw how he was in the middle innings. He got that curveball over and was getting all of his pitches. He found his rhythm."
Marlins: Hoping for better results on the road
The Marlins' nine-game road trip includes stops in San Francisco, San Diego and Houston. Miami was 0-5 on its previous road trip, being swept in Washington and New York.
Lefty Dan Jennings, who was called up from Triple-A New Orleans for Monday's game, threw a scoreless inning against the D-backs, while walking one batter.
Nolasco owns a strikeout-to-walk ratio of 4.09 since 2008, which ranks fourth among all active Major League starters (Roy Halladay, Cliff Lee and Dan Haren). He averages 1.95 walks per nine innings, which is sixth among active starters.
Giants: Hitting well, Belt sits Sunday
Brandon Belt's offensive performance is picking up: In his six games prior to Sunday, he was hitting .375 (6-for-16) with three doubles and five RBIs.
He did not start Sunday in a 4-1 loss to San Diego, with Padres left-hander Clayton Richard on the mound, but he figures to return to the mix Tuesday with the right-handed Nolasco on the mound for Miami.
Sixteen of the Giants' 22 games this season have been decided by three runs or fewer.
The Marlins won four of the six meetings between the two clubs last year, including a three-game sweep in San Francisco from May 24-26. Since July 8, 2009, Miami is 6-2 at AT&T Park, with a team ERA of 3.15.