He will try to remove the zero from his line Thursday when the Indians go for their fourth straight road series win to start the season, a feat the club hasn't accomplished since 1961.
The Tribe is 8-3 away from home this season.
On April 5, Masterson threw eight innings and gave up one run to the Blue Jays but received a no-decision. On Sunday, he held the Angels to two runs over 8 1/3 innings but again didn't factor into the decision.
"We had a lot of opportunities offensively and they stayed in the game," Masterson said after the game. "Our guys did great scoring a couple more runs to tie it up."
Trying to help Masterson get that elusive first win will be new Indians outfielder Johnny Damon.
He went 0-for-3 with a walk in his debut on Wednesday before being taken out in the sixth inning because of cramping.
Going for the White Sox will be John Danks, who had an April to forget, posting a 6.23 ERA while giving up a team-high 31 hits and 15 walks over 30 1/3 innings.
In his last start, Danks took the loss against Boston, allowing seven runs on six hits. He has allowed a home run in four of his five starts this season.
Despite the negative results, Danks isn't feeling any pressure from signing a five-year, $65 million deal during the offseason.
"I haven't even thought about it. It never comes up. It's a non-issue," Danks said. "I obviously understand the questions and what not, but that hasn't been the issue one time."
The main issue for Danks this season is finding consistency in his pitches throughout an outing.
"Everything is kind of coming and going," he said. "We've been working hard and doing the things we need to do. But I would like to start seeing some results."
White Sox: Peavy AL's best April pitcher
After going 3-1 with a 1.67 ERA, 33 strikeouts, two complete games and one shutout during the opening month, Jake Peavy was voted the American League Pitcher of the Month for April on Wednesday.
He has won the award four times before, including three times in 2007 when he won the National League Cy Young Award.
"It's certainly exciting to be back healthy and doing what I had done before getting here," Peavy said. "That's something I feel blessed to be able to do. But at the same time, one month doesn't prove anything. It shows, hopefully, I'm healthy and can put together a few more like this one and call it a good year."
Indians: Brantley adjusting to Damon
With Damon now in the mix, leadoff hitter Michael Brantley will share his spot in the batting order with the veteran.
On Wednesday, Brantley hit seventh and Damon batted first. Despite the changes, Brantley is happy to have the 38-year-old around.
"He's phenomenal," Brantley said. "He's just a class-act person. He's already taking young guys in and teaching them some things. We were talking about different situations already. He's a pleasure to have."
The Indians' bullpen has tossed 15 2/3 consecutive scoreless innings over the club's last six games.
Paul Konerko needs one hit to move past Eddie Collins (2,007) into sole possession of fourth place in White Sox history.