The last time the Angels took the drive down the I-5 in 2000, the Padres were still playing at Qualcomm Stadium. Petco Park opened in 2004.
Jered Weaver and Jeff Suppan will be on the hill for the teams in the opener of the weekend Interleague series.
After giving up just one earned run in 21 innings over three starts, Weaver had one the worst outings of his career on Mother's Day against the Rangers. He allowed eight earned runs on 10 hits over 3 1/3 innings in a 13-6 loss.
"Nothing you can do but go back out there and do what you know what to do and keep battling," Weaver said. "That's baseball. You're going to have four or five of those starts a year, it's a given, and it's just a matter of how you bounce back from it.
The only other time the 29-year-old faced the Padres was in June 2009, when he tossed his first career shutout, surrendering only six hits.
"I'll look at film. I'm sure they have a few guys on their team that they didn't have last time," Weaver said. "I don't really worry about what I did against them last time. It's a new team. I'll look at some video when I get to the field tomorrow and go from there."
Suppan is coming off his first defeat of the season, a 3-2 loss to the Phillies. He gave up two earned runs over six innings in the outing.
"He hasn't pitched in the Major Leagues since 2010 and he's got a great perspective on what it takes to be a Major League player," Padres manager Bud Black said. "He's not taking anything for granted. He understands his place."
Suppan will be making his first appearance against the Angels since Aug. 19, 1996, when he was pitching for the Red Sox. He is 5-3 with a 4.87 ERA in his career against the Angels.
Angels: Pujols returns to National League
The beginning of Interleague Play also means a return to National League competition for Angels slugger Albert Pujols, whose quixotic search for normalcy has been one of the defining stories of the young season.
Pujols, who spent the first 11 seasons of his career with the Cardinals in the NL Central, hasn't produced to his usual standards in his first American League season. Though Pujols enters Friday with homers in back-to-back games, he also has a .214 batting average and .248 on-base percentage. His career average, even with his struggles this season, stands at .326, with a .417 OBP.
Pujols' numbers at Petco aren't up to his career standards, either -- .258 average, .345 OBP. It's not worth much, because he changed leagues in the offseason, but Pujols is a .348 hitter in 143 Interleague games, with 39 homers and a .438 OBP.
Padres: Hudson released, Bartlett to DL
Padres executive vice president and general manager Josh Byrnes announced Thursday the Padres have requested unconditional release waivers on infielder Orlando Hudson, placed infielder Jason Bartlett on the 15-day disabled list with a strained right knee and recalled infielders Everth Cabrera and Alexi Amarista from Triple-A Tucson.
"We felt it was time to make a change," Byrnes said. "O-Dog has been a two-time All-Star, four-time Gold Glove winner and a contributor to playoff teams, but at this point, we want to give our younger players an opportunity."
Hudson hit .211 (26-for-123) with five triples, one home run, 11 RBIs and 11 runs scored in 35 games for the Padres this season.
Bartlett has hit .133 (11-for-83) with five doubles, four RBI and eight runs scored in 29 games in his second year with the Padres.
Left fielder James Darnell exited Thursday's game against the Dodgers with what the team called a left shoulder subluxation (partial dislocations). Darnell suffered the injury attempting to make a leaping catch on a Tony Gwynn liner to lead off the sixth inning. The ball fell for a double.
The Angels and Padres have met 22 times in Interleague Play, splitting the games 11-11.
The Angels have gone five straight games without committing an error, 51 consecutive innings.
Suppan's 414 Major League starts rank fifth among active players (Jamie Moyer, Andy Pettitte, Livan Hernandez and Kevin Millwood).