For the Mariners, however, a .500 or better mark against the National League has become almost an annual occurrence.
Both the Padres and Mariners have been solid during Interleague Play this season, and they each have the chance to finish .500 or better with a win in Sunday's rubber match at Petco Park.
The Padres, who are currently 7-7 against the AL, have finished better than .500 in Interleague Play just twice in their history -- in 1999 and 2010. They broke even in the first year of Interleague Play, posting an 8-8 mark in 1997.
Meanwhile, the Mariners, who are 8-9 against the NL, need a win to extend their streak of a .500 record or better to 13 straight seasons. The streak dates back to 2000, and is the second longest in baseball, behind only the Yankees.
Edinson Volquez gets the ball for San Diego with eyes on snapping that streak. He has just one win since May 12, but that win came against the Mariners in a 6 2/3 inning effort during which he allowed just one run.
Volquez (3-7, 4.11 ERA) struggled his last time out, allowing six runs in five innings. He allowed five hits and struggled with his control, walking four.
Opposing Volquez will be right-hander Hector Noesi, who is just 11 days removed from losing a 1-0 ballgame to the Padres in Seattle. Against Arizona on Monday, Noesi gave up six runs (five earned) and nine hits.
Noesi got behind quickly in that game, but manager Eric Wedge saw some things he liked.
"He got better as the game wore on," Wedge said. "He got better with two strikes, but he has to have that in his back pocket. He has to be more aggressive, and he has to do it from the very first pitch of the very first inning."
Wedge continues to say that the 25-year-old is learning with each outing and now needs to develop the consistency that comes with the job.
"When it comes to being a big league starter -- and this is a guy we feel like can be that for a long time once he gets more consistency -- you have to bring it 30 to 35 times [each season]," Wedge said.
Mariners: Gutierrez nearing full strength
Mariners center fielder Franklin Gutierrez had four hits on Friday night, and although he went 1-for-5 on Saturday, he feels he's nearly ready to see action on a daily basis.
"I think I'm getting to that point. We talk about it," he said. "Obviously, I'm still feeling some soreness and all that kind of stuff. But I'm getting to the point I'm feeling better with my legs, and that's the most important thing for me. As soon as I feel ready with my legs, I'm going to be ready to play every day."
Gutierrez tore his right pectoral muscle in Spring Training, and suffered plantar fasciitis during his rehab. He is hitting .290 in 31 at-bats this year.
The Mariners are hitting .295 with eight homers during the first five games of their current road trip.
Padres: Forearm tightness derails Owings
Padres right-hander Micah Owings was very close to returning to the big league club when he suffered a serious set-back in his rehab that forced the team to shut him down.
Owings, who has been on the disabled list since April 26 with right-forearm tightness, felt soreness in that forearm while warming up for a rehab outing with Triple-A Tucson.
"He's back to, I wouldn't say square one, but it's a setback," manager Bud Black said.
Padres outfielder Chris Denorfia didn't record an at-bat on Saturday, but he is riding a 10-game hitting streak -- tied for the longest by a Padres hitter this season. He is hitting .395 during the streak.
Third baseman Chone Figgins is the only Mariner with an extra-base hit against Volquez. In five at-bats, Figgins has four hits, including a homer.
Mariners pitchers have recorded 30 shutouts during Interleague Play since its inception in 1997 -- the most in the Majors.
Seattle leads the all-time series over San Diego, 45-40, including wins in 20 of their last 32 meetings.