The Major League Baseball schedule for 2010 was released on Tuesday, and it has the A's opening the season at home against the Seattle Mariners, whom they'll face seven times in their first 10 games.

Also among the home highlights: two visits each from the New York Yankees (April 20-22, July 5-7) and Boston Red Sox (July 19-21, Sept. 10-12), the annual series against the cross-bay rival San Francisco Giants (May 21-23), and a six-game stretch of Interleague Play against the National League Central's Cincinnati Reds (June 21-23) and Pittsburgh Pirates (June 24-27).

The road portion of the schedule starts after the conclusion of a four-game set against the Mariners to open the season (April 5-8), taking Oakland to Anaheim for a three-game weekend series against the Angels (April 9-11) before a trip up to Seattle for three games (April 12-14).

After that comes a 10-game homestand featuring four against the Baltimore Orioles, the Yankees' first visit and a three-game set against the Cleveland Indians.

The road-trip highlight for Oakland: an Interleague trip that starts just across the Bay Bridge for three games at the Giants' AT&T Park (June 11-13), continues on to Wrigley Field for a three-game series against the Chicago Cubs (June 15-17), followed by three games with the Cardinals at Busch Stadium (June 18-20).

The A's don't get their first look at the Texas Rangers, the surprise team of the American League West in 2009, until Texas comes to Oakland-Alameda County Coliseum on May 3-5.

The last homestand of the year also features the Rangers (Sept. 23-26), setting up a season-ending road trip to Anaheim (Sept. 27-29) and, fittingly, Seattle (Sept. 30-Oct. 3).