| Hitter | AVG | AB | HR | RBI |
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Hernandez will make his fifth Opening Day start and third straight for Seattle, looking to repeat last year's performance in which he threw a complete-game victory over the A's. He is 3-0 with a 1.70 ERA in prior Opening Days.
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McCarthy gets the Opening Day nod for the A's after posting a 3.32 ERA in 25 starts last season. He allowed nine runs (six earned) in 11 2/3 innings this spring and is 2-5 with a 4.20 ERA in 11 games (nine starts) against the Mariners in his career.
| Hitter | AVG | AB | HR | RBI |
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Vargas has moved up to No. 2 in Seattle's rotation and gets a shot against the A's in Tokyo. He's 1-3 with a 3.86 ERA in five career starts vs. the A's.
| Hitter | AVG | AB | HR | RBI |
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Colon is coming off an impressive season, going 8-10 with a 4.00 ERA with the Yankees after not pitching in 2010. Colon allowed four earned runs in 6 2/3 innings in Spring Training. He is 14-11 with a 4.13 ERA in 29 career starts against Seattle.