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Vargas faces Oakland for a second straight game, having gone 6 1/3 innings with one run on two hits in last Thursday's 4-1 loss in the Opening Series in Tokyo. He's 3-4 with a 3.97 ERA in nine career games vs. A's.
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More than a week removed from his Opening Series start vs. Seattle in Tokyo, McCarthy is set to take the mound a second time vs. the Mariners. On March 28, he held them to one run in seven innings with three K's, but left with a no-decision.
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Hernandez came out strong with eight innings of one-run ball against the A's in a no-decision last Wednesday in the Opening Series in Japan. He stayed sharp with four shutout innings vs. Colorado in a Cactus League start Monday.
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Colon christened his 15th season in the Majors by capturing a well-deserved victory against the Mariners in Tokyo on March 29. The righty didn't give up a hit until the fifth and allowed just three overall and one run in eight crisp innings.
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A Cactus League sensation, Mendoza's spot as the fourth starter was finalized when Felipe Paulino went on the disabled list. Mendoza revamped his pitching style in Triple-A the past two years and turned his sinking fastball into a potent weapon.
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Milone, who showcased near-perfect command all spring, is set to make his season debut. In his final two exhibition starts -- one against Triple-A Sacramento and another vs. the Giants -- the lefty struck out 13 in a combined 11 scoreless innings.
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Blessed with a hot fastball and extraordinary stuff, Duffy is still searching for consistency in the Majors. He made 20 starts last year after coming up from Omaha and finished 4-8 with a lot of strikeouts -- and walks.
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Godfrey, who pitched five shutout innings against the Giants in his final exhibition start, was named the No. 4 starter two days later and is now set for his season debut. He went 1-2 with a 3.96 ERA in five games (four starts) for the A's last year.